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5.2.2.5.1 Synthesis of O -permethyltellimagrandin I
Nelson and Meyers (1994) were able to synthesise enantiopure ( S ) -
hexamethoxydiphenic acid ( S ) - 50 using the asymmetric Ullmann
coupling of two chiral ( S ) - bromooxazolines 48 . The diastereomerically
pure biaryl compound ( S , S , S )- 49 was obtained in 58% yield, and was
then converted in three steps via an acid-catalysed cleavage of the
oxazoline residues into ( S ) - 50 (Fig. 5.10).
Fig. 5.10 Synthesis of O -permethyltellimagrandin I ( 53 ).
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