Biology Reference
In-Depth Information
and strategies will be augmented, not replaced, by embedding them into
the arsenal of recently developed and emerging advanced technologies,
from genomics and proteomics to comprehensive metabolomics.
HO
OH
OH
HO
OH
HO
HO
HO
OH
O
HO
O
HO
HO
O
O
O
O
O
HO
O
O
O
O
O
O
O
O
OH
HO
O
OH
O
O
OH
O
OH
O
OH
OH
O
HO
OH
OH
O
OH
OH
HO
HO
OH
4
4
HO
OH
- H
2
O
OH
HO
OH
HO
OH
HO
HO
O
HO
O
HO
O
6
O
O
HO
1
O
HO
O
4
HO
O
2
O
O
O
O
HO
OH
O
3
HO
O
4'
O
6'
O
OH
OH
O
O
O
OH
3'
2'
1'
HO
O
HO
O
OH
OH
O
HO
O
OH
HO
OH
22
HO
OH
Fig. 3.13 Enzymatic dimerization of tellimagrandin II (
4
) into cornusiin E (
22
) by a
laccase-type phenolase from
Tellima grandiflora
(fringe cups) leaves, affording an (
S
)-
2,4',6'-valoneoyl bridge between the two monomeric units. Reaction sites are marked by
square boxes and red arrows.
HO
Acknowledgements
I am grateful to the many colleagues and co-workers that have
contributed to the research reported in this chapter and deeply thank
them for their input of advice, enthusiasm and skill, or for having
provided rare chemicals. Generous financial support provided for many
years by the Deutsche Forschungsgemeinschaft (Bonn) and the Fonds
der Chemischen Industrie (Frankfurt) is gratefully acknowledged.
