Biomedical Engineering Reference
In-Depth Information
Hydrophobic
Hydrophilic
Precursor
(1)
Diffusion into cell
Enzyme
Intracellular enzymatic
cleavage
(2)
Hydrogelator
Intracellular self-assembly
and cell-death
(3)
Nanofiber
(a)
O
O
O
H
x
N
N
H
N
OH
H
O
O
57
57
X = O
58
X = NH
H
2
O
Estrase
59
O
O
O
H
OH
OH
N
H
HO
H
O
O
59
60
(b)
Figure 1.36
(a) Schematic intracellular formation of nanofibers that leads to hydrogelation
and cell death. (b) The chemical structures and graphic representations of the precursor
(
57
), the control molecule (
58
), and the hydrogelator (
59
). Reprinted with permission from
Ref. [111]. Copyright 2004 Wiley.
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