Biomedical Engineering Reference
In-Depth Information
B:
O
OH
O
OH
O
P
NH
2
HO
N
O
O
NH
N
O
N
N
N
B
B
B
OH
OH
N
N
N
H
H
H
H
O
OH
H
O
O
O
O
O
O
O
T
A
1
2
3
O
NH
2
N
NH
N
N
NH
2
N
O
N
O
O
C
G
(a)
A
G
T
C
0 h
20 h
1
3
(a)
(b)
Figure 4.9
(A) Molecular structures and
shapes of the nucleopeptidehydrogelators
and their corresponding precursors. (B) TEM
micrographs of the hydrogels formed by nu-
cleopeptides 1A, 1G, 1T, 1C, 3A, 3G, 3T and
the solution of 3C; Scale bar
=
100 nm. (C)
Result of a simple wound healing assay rep-
resented by optical images of HeLa cells on
the surface 0 and 20 hours after creation of
scratches in the presence of hydrogelator 3T.
(Figure adapted from Ref. [81] (Copyright
2011) John Wiley & Sons, Inc.)
hydrogen bonding on the packing and morphology of the gel's self-assembled
structures.
4.4.4.2
Nucleic Acid Chains
Nucleic acids are polymerized nucleotides, existing usually as double-stranded
structures, with each strand carrying a nucleotide sequence complementary to
the other, linked together by inter-base pairs hydrogen bonding. Even though the
molecular weight of nucleic acids may be considerably larger than the arbitrary limit
of 3000 Da set forth by some literature, they are still included here, owing to their
inherent biocompatibility, the ability to self-associate via non-covalent interactions,
the ease of breaking down the resultant gels, the ability to design specific nucleotide
sequences to alter gelation properties, and their diverse and promising potential in
the field of biomedical research.
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