Is It Possible to Differentiate the Impact of Pediatric Monophasic Demyelinating Disorders and Multiple Sclerosis After a First Episode of Demyelination? - Longitudinal Registration and Shape Modeling - page 41

growth trajectory creation (
time of the first attack (cyan
of the patient at the time of
and sex-matched NIHPD no

(black curve in (a)), estimation of the brain volume at
n point in (a)), brain growth rate (slope of the tangent li
f the first attack (red slope in (b)), brain growth rate for
ormal controls (blue slopes in (b)), slope comparison (c)

the
ine)
age
).

Fig. 3. Example of brain grow
first attack (a) in green: brain
growth curve - in cyan: value
curve (b) in cyan: value of th
growth curve, in red: tangent l
dark blue: tangent line of the
NIHPD group (c) in red: brain
brain growth rates of the age a

wth rate comparison for a male patient, 15 year old at the ag
volume computed at 7 visits - in black: estimated brain volu
e of the brain volume at first attack predicted using the gro
he brain volume of the patient at first attack estimated using
line of the brain curve estimated at the time of the first attack
e brain curves of the age and gender-matched subjects from
n growth rate (slope of the tangent line) of the patient - in b
and gender-matched subjects

ge of
ume
owth
g the
k, in
m the
blue: