Is It Possible to Differentiate the Impact of Pediatric Monophasic Demyelinating Disorders and Multiple Sclerosis After a First Episode of Demyelination? - Longitudinal Registration and Shape Modeling - page 40

i and E ij is the error for time
have mean zero and constan
Two models with the
age3*sex) were computed t
for the patient group. Tw
computed for the NC and N
The brain and normalize
subjects are represented Fig

e point j in subject i . The errors for subject i are assumed
nt variance and be independent of the vectors (ʳ 0 i , ʳ 1 i ).
same fixed effects (age, age2, age3, sex, age*sex
to estimate brain growth and normalized thalamus grow
o other brain and normalized thalamus models were a
NIHPD groups.
ed thalamus growth trajectories of all patients and NIH
g. 2.

d to

and
wth
also

HPD

Fig. 2. Model fits of the brai
curves (bottom) for the patient

n volume growth curves (top) and normalized thalamus gro
ts (left) and the normal controls from NIHPD (right)

owth

3.2 Growth Rate and V Volume z-score Group Comparison

Figure 3 represents an exam
tion for a 15 yo patient: bra

mple that illustrated the four steps of the z-score compu
ain volume computed at 7 visits (green curve in (a)), br

uta-
rain