Chemistry Reference
In-Depth Information
In the early stages of Drosophila embryonic development, initial nuclear clea-
vages are not accompanied by cell division, creating a large multinucleate syncy-
tium in a broad band of cortical cytoplasm (periplasm) where zygotic transcription
begins at the blastoderm stage. The nuclei form a layer subdividing the periplasm
into two compartments: the apical, above the nuclei, and the inner, basal periplasm
below the nuclei. The pair-rule mRNAs, essential for the further segmentation of
the embryo, are restricted in the apical compartment. Their localization mecha-
nism requires speci
csequencesinthe3
0
UTR of the transcripts [103], Squid
protein to promote apical transport [104] and dynein-mediated transport on
microtubules [105, 106].
8.5
Conclusion
We now knowmuch about howRNA travels from its birth place to its functional sites.
However much more needs to be known and new tools need to be developed to fully
understand the process. The study of single molecules in live cells is becoming
essential to discover the connections between different pathways and the actual
mechanisms for regulating gene expression in the cell.
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