Specialized Chromosomes and Their Uses in Caenorhabditis elegans - Caenorhabditis Elegans: Molecular Genetics and Development - page 35

Table III
A listing of genomic balancers that are available for use in C. elegans but are not fully characterized

Balancer name Region covered Use Stability Origin

hDp102 (I;X)
( McKim et al.,
1993 )

Duplication of chromosome
I(unc-40 to just past
unc-9) inserted between
unc-7 and dpy-3 on the X
chromosome

Very stable 1500-3000 R gamma

irradiation

hDp14 (I;X) ( McKim
and Rose, 1990;
McKim et al., 1993 )

Duplication of chromosome
I inserted between unc-2
and dpy-8 on the X
chromosome

Very stable 1500-3000 R (0.9-7.5 R/s)

gamma irradiation

sC1 (III) [D. Baillie,
pers. comm.]

LG III from unc-45 to
daf-2

Very stable 2000 R gamma irradiation

mutagenesis

sC4 (V) [D. Baillie pers.
comm.]

Right LG V from rol-9 to
unc-76

2000 R gamma irradiation
mutagenesis

UVmutagenesis (120 J/m 2 ) sDp8 ( Stewart et al.,

1991 )

Covers unc-36 but does not
cover sma-2

Stable

UVmutagenesis (120 J/m 2 ) sDp9 ( Stewart et al.,

1991 )

Covers unc-36 and sma-2 Stable

sDp30 (V;X)
( McKim et al.,
1993 )

Inserted between dpy-7 and
unc-3 on chromosome V

Stable

sT1 (III;X) [D. Baillie,
pers. comm.]

Possible translocation Unconfirmed

Possibly
Reduces crossing over on
LG III between sma-2
and unc-64

1500 R gamma irradiation
mutagenesis

sT2 (IV;V) [D. Baillie,
pers. comm.]

Possible translocation;
covers unc-46

Unconfirmed 1500 R gamma irradiation

mutagenesis

sT3 (III;V) [D. Baillie
pers. comm.]

Possible translocation;
putatively covers unc-36,
sma-2 and unc-46

Unconfirmed 1500 R gamma irradiation

mutagenesis

sT4 (III; likely V)
[D. Baillie pers.
comm.]

Possible translocation; left
LG III to between unc-36
and sma-2 and covers
unc-46 on LGV

Unconfirmed 1500 R gamma irradiation

mutagenesis

120 J/m 2 UV irradiation
mutagenesis

sT5 (II;III)
( Stewart et al.,
1991 ) [D. Baillie
pers. comm.]

Possible translocation Unconfirmed

Reduces crossing over on
LG III between sma-2
and unc-64

does occur, crossover products generate duplications and deletions, and often result
in inviable animals ( Zetka and Rose, 1992 ). As homozygotes, inversions are gener-
ally viable, pair properly, and exhibit normal levels of recombination. In C. elegans,
two inversions have been well characterized. hln1(I) ( Zetka and Rose, 1992 ) and
mlnl

(II) ( Edgley and Riddle, 2001 ). In hlnl, a large portion of the right half of