Agriculture Reference
In-Depth Information
Table 7.1 Components of the core and selective autophagy in
Saccharomyces cerevisiae
,
Homo
sapiens
and
Arabidopsis thaliana
and the examples of loss of function phenotypes of autophagy
mutants in plants
Saccharomyces
cerevisiae
(number of
residues)
Selected
references
related to plant
phenotypes
Homo sapiens
(number of
residues)
Arabidopsis
thaliana
(number
of residues, gene)
Loss of function
phenotype in
plants
Initiation (ATG1 kinase complex)
a
TOR1 (2470);
TOR2 (2474)
FRAP1/mTOR
(2549)
TOR (2841,
At1g50030)
Cell, organ,
seed production
and resistance to
osmotic stress
decrease. Post-
germinative
arrest in growth
and develop-
ment. Early
senescence
Leiber
et al. (
2010
),
Johansen and
Lamark (
2011
),
and Deprost
et al. (
2007
)
ATG1 (897)
ULK1 (1050),
ULK2 (1036)
ATG1a
(626, At3g61960);
ATG1b
(711, At3g53930);
ATG1c
(733, At2g37840);
ATGt
(408, At1g49180)
Accelerated
senescence,
both fixed C and
N starvation
sensitivity
Suttangkakul
et al. (
2011
)
ATG13 (738)
HARBI1/
mATG13 (349)
ATG13a
(618, At3g49590);
ATG13b
(625, At3g18770)
Accelerated
senescence,
both fixed C and
N starvation
sensitivity
Suttangkakul
et al. (
2011
)
and Kim
et al. (
2012
)
ATG17 (417)
FIP200/RBCC1
(1594)
ATG17 (three
potential isoforms:
1022, At2g37420;
376, At1g59580
[weak interaction
with ATG9]; 1516,
At4g28710)) -see
next column
No phenotype
data. Exact
yeast homo-
logue still
unclear
b
-
ATG29 (213)
Not found
Not found
-
-
ATG31 (196)
Not found
Not found
-
-
Not found
ATG101 (218)
ATG101
(215, At5g66930)
-see next column
No phenotype
data. Exact
yeast homo-
logue still
unclear
b
-
KOG1/RAP-
TOR (1557)
RAPTOR
(1335)
RAPTOR1/1b
(1344,
At3g08850); RAP-
TOR2/1a (1336,
At5g01770)
Post-embryonic
meristem-
driven growth
affected in dou-
ble mutants.
Single mutant
phenotypes
differ
Anderson
et al. (
2005
)
and Deprost
et al. (
2005
)
