Breast cancer and non-malignant breast data: Quantification by FPT - Signal Processing in MRS with Biomedical Applications - page 329

Exact Reconstructions of Metabolite Concentrations by FPT (−) : Partial Signal Length N P = 1500
Types of Tissue on Three Panels : (i) Normal, (ii) Fibroadenoma, (iii) Malignant
Two Sets of Independent Abscissae and Ordinates: [Bottom,Left] ## 3−9 (Cho,...,m−Ins) and [Top,Right] ## 1, 2 (Lac,Ala)

Metabolite Map for Concentrations: x (Input Data), o (Pade−Reconstructed Data)

2.6 2.32 2.04 1.76 1.48 1.2

0.5 0.6

PADE: FPT (−)
N P = 1500
CONVERGED
ν L = 600 MHz
B 0

7
(3.25 ppm, 0.45

0.4 0.48

µ M/g ww) 1

(1.33, 0.504)
Lac

m−Ins

β −Glc

(3.28, 0.286)

9

0.3 0.36

≈ 14.1 T

Tau PE

Normal

0.2 0.24

(3.27, 0.1325) (3.22, 0.129)

8

5

Ala

(1.47, 0.0875)

0.1 0.12

2

GPC

PCho (3.22, 0.019)

6
(3.23, 0.032)

4 3 Cho

(3.21, 0.017)

0 0

3.3 3.26 3.22 3.18 3.14 3.1

(i) Chemical shift (ppm)

Metabolite Map for Concentrations: x (Input Data), o (Pade−Reconstructed Data)

2.6 2.32 2.04 1.76 1.48 1.2

1.05 1.6

PADE: FPT (−)
N P = 1500
CONVERGED
ν L = 600 MHz
B 0 ≈ 14.1 T
Fibroadenoma

7
(3.25 ppm, 0.978

1
(1.33, 1.482)
Lac

µ M/g ww)

0.84 1.28

β −Glc

m−Ins

0.63 0.96

(3.28, 0.465)

PE

9

(3.22, 0.369)

5

0.42 0.64

8
(3.27, 0.338)
Tau

Ala

PCho

0.21 0.32

GPC (1.47, 0.110)

4 (3.22, 0.108)

2

6
(3.23, 0.0690)

Cho

3

(3.21, 0.0220)

0 0

3.3 3.26 3.22 3.18 3.14 3.1

(ii) Chemical shift (ppm)

Metabolite Map for Concentrations: x (Input Data), o (Pade−Reconstructed Data)

2.6 2.32 2.04 1.76 1.48 1.2

3 10

Lac

PADE: FPT (−)
N P = 1500
CONVERGED

8
(3.27 ppm, 2.7955 µ M/g ww)
Tau

1

PE

2.4 8

(1.33, 8.1185)

(3.22, 1.944)

5

1.8 6

ν L = 600 MHz
B 0 ≈ 14.1 T
Malignant

m−Ins

1.2 (3.28, 0.891) β −Glc 4

9 (3.25, 0.7205)

7

PCho

Ala

0.6 (3.22, 0.612) 2

GPC (1.47, 0.789)

4

6 2

3 Cho

(3.21, 0.1115)

(3.23, 0.234)

0 0

3.3 3.26 3.22 3.18 3.14 3.1

(iii) Chemical shift (ppm)

FIGURE 10.8
Converged Padereconstructed metabolite concentrations N P = 1500 for nor
mal breast tissue breast tissue (top panel (i)), benign breast pathology (fi
broadenoma) (middle panel (ii)) and breast cancer (bottom panel (iii)) based
upon in vitro data of Ref. [395].