Travel Reference
In-Depth Information
Proton pump inhibitors, of which the best known are omeprazole (Prilosec®) and
esomeprazole (Nexium®), block secretion by the acidproducing cells of the stomach.
These agents are the most effective yet developed for treating peptic ulcer and gastroeso-
phageal reflux (heartburn). No contraindications exist, although the safety of the drug dur-
ing pregnancy and in children has not been established. No significant side effects occur
during administration for the short intervals that would typify wilderness outings.
Omeprazole is available over the counter. A physician's prescription is required for
esomeprazole.
Speed of Action
Antacids provide the most rapid relief for symptoms of indigestion and heartburn. H
2
blockerstakeeffectrelativelyquickly.Protonpumpinhibitorstakelongertotakeeffectbut
are the best for long-term care.
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