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30,000 individuals a year in Africa even though most infections are mild and the mortality
rate is only about 15 percent. Only two infections each by Ebola Tai and Ebola Sabia (or
Brazilian hemorrhagic fever) have been recognized.
These infections share the feature of frequent, although not universal, bleeding into the
skin, into the gastrointestinal tract, and from body orifices. However, the unfortunate indi-
viduals who contract hemorrhagic fever die as the result of organ failure, usually liver or
kidney failure; they do not bleed to death.
The viruses that cause these infections have highly specific animal reservoirs, and the
infections are limited to areas where those animals are found. For instance, the reservoir
for Argentine hemorrhagic fever is two species of rat found only in cornfields in northern
Argentina, and the infection is limited to that area. However, hemorrhagic fevers of one
type or another are found over most of the globe, and the reservoir for one such infection,
Seoul hemorrhagic fever, is the common rat or Norwegian rat, which is found everywhere.
Dengue, which can produce dengue hemorrhagic fever, is found throughout the tropical
world.
Table 22-1
Viral Hemorrhagic Fevers
VIRUS FAMILY
CLINICAL DISORDER
METHOD OF SPREAD
Bunyaviruses
Hantavirus Hemorrhagic Fever with Renal
Syndrome
Rodent contact
Hantavirus Pulmonary Syndrome
Rodent contact
Crimean-Congo Hemorrhagic Fever
Direct contact or tick borne
Rift Valley Fever
Mosquito borne
Flaviviruses
Yellow Fever
Mosquito borne
Dengue Hemorrhagic Fever
Mosquito borne
Kyasanur Forest Disease
Tick borne
Tick-borne Encephalitis
Tick borne
Omsk Hemorrhagic Fever
Tick borne
Filoviruses
Marburg Disease
Bats and direct contact
Ebola Sudan
Bats and direct contact
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