A Novel Method for DNA Microarray Data Analysis: SDL Global Optimization Method - DNA Microarray Technology and Data Analysis in Cancer Research - page 51

Table 4.3. The number of significant downregulated genes among P190, P210, and
P230 with FC < − 2 for P190 and P230 and FC < − 3 for P210.

P190 + P210 + P230 P190 + P210 P190 + P230 P210 + P230 P190 P210 P230

19 5 1 27 0 >56 16

Fig. 4.7. Distribution of the significantly upregulated genes across P190, P210, and P230.

The examples illustrated above briefly show the capacity of simulta-
neously analyzing the expression of all genes detected by DNA microar-
ray using our SDL global optimization method. In the next chapter, we
will show more examples of applications of the SDL global optimization
method in analysis of our and publicly available microarray data for the
molecular classification of leukemia.

4.4. More Information on SDL Global Optimization

Since the fold change does not address the reproducibility of the observed
difference and cannot be used to determine the statistical significance, raw