Applications of DNA Microarray Technology in Cancer Research - DNA Microarray Technology and Data Analysis in Cancer Research - page 18

Table 2.1. Gene expression patterns of BCR-ABL-expressing cells treated with or
without imatinib (IM).

Gene expression levels in experimental
groups

Expression
pattern Control BCR-ABL BCR-ABL + IM Explanation

A +++ +++++ +++ positively involved

B +++ + +++ negatively involved

C +++ +++++ +++++ or ++++ positively involved

D +++ + + or ++ negatively involved

E +++ +++++ +++++++ negatively involved

F +++ ++ + positively involved

G +++ +++ + positively involved

H +++ +++ +++++ negatively involved

I +++ +++ +++ not involved

• Expression of a gene is downregulated by BCR-ABL as compared to

the control, and imatinib treatment increases the expression level of
the gene toward or to the control level (Pattern B).

• Expression of a gene is upregulated by BCR-ABL as compared to the

control, and imatinib treatment does not reduce the expression level of
the gene toward or to the control level (Pattern C).

• Expression of a gene is downregulated by BCR-ABL as compared to

the control, and imatinib treatment does not increase the expression
level of the gene toward or to the control level (Pattern D).

• Expression of a gene is upregulated by BCR-ABL as compared to the

control, and imatinib treatment further increases the expression level
of the gene (Pattern E).

• Expression of a gene is downregulated by BCR-ABL as compared to

the control, and imatinib treatment further reduces the expression level
of the gene (Pattern F).

• Expression of a gene is not changed by BCR-ABL as compared to the

control, and imatinib treatment reduces the expression level of the
gene (Pattern G).