Biology Reference
In-Depth Information
disease situations. In addition, the procedures can easily be automated.
Furthermore, the capacity of measurement of gene expression by DNA
microarray is huge, allowing researchers to take the expression of all
genes from an individual into consideration for disease analysis in so-
called “personalized medicine”.
One of the major disadvantages of DNA microarray technology is that
it only evaluates gene expression at a transcriptional, but not translational,
level, as posttranscriptional modifications (such as phosphorylation) often
play significant roles in the regulation of protein functions. In addition,
DNA microarray technology is still not mature enough for decision
making based on the microarray data. In this topic, we introduce our new
way of interpreting and analyzing microarray data, which will hopefully
bring us closer to success in decision making using the information
obtained through DNA microarray technology (see Chapter 4).
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