Environmental Engineering Reference
In-Depth Information
-MEND)
liposomes encapsulating a 2
0
-O-Methyl RNA complementary to a micro RNA to
suppress insulin secretion and the knockdown of the targeted micro RNA with an
up-regulation of insulin secretion were observed in pancreatic
The multifunctional envelope-type nanodevice for pancreatic
β
cells (
β
β
cells line, MIN6.
β
Thus, the
-MEND has the potential as an efficient nucleic acids delivering system
targeted for efficient internalization in MIN6 for application in research and therapy
based treatments of diabetes [
72
].
Multifunctional nanosized liposomes incorporating the lipid-PEG-curcumin
derivative with a Blood-Brain Barrier (BBB) transport mediator (anti-Transferin
antibody) showed a high affinity for the amyloid deposits in brains and thus were
targeted
for
treatment
and
diagnosis
of Alzheimer Disease
affected
individuals [
73
].
The applicability of the nanocarrier systems
viz.
liposomes, nanoparticles, and
nanoemulsion acting as nanotherapy for posterior eye diseases to defy ocular
barriers, target retina, controlled release, and act as permeation enhancers is highly
appreciable for treatment of blindness, the second most dreaded disease across
the world [
74
].
The AeroEclipse II nebulizer for the delivery of pDNA complexed with the CLP
like GL67A (pDNA/GL67A) formulations has efficacy to deliver aerosol slowly,
generate aerosol only during the inspiratory phase, and biological function of
pDNA/GL67A formulations was retained after nebulization. Thus this device was
more efficient than other control devices in lung gene therapy for generating aerosol
available for cystic fibrosis and for a range of acute and chronic diseased patients
'
inhalation [
75
].
Nanoliposomes complexes reduce the risk of systemic toxicity and increase the
patient compliance in fatal respiratory infectious diseases like tuberculosis as
compared to oral conventional anti-tuberculosis therapy [
76
].
For intrinsic adjuvanticity of the immunoadjuvant for SLA, 1,2-dioleoyl-3-
trimethylammonium-propane (DOTAP) nanoliposomes containing SLA are
appropriate delivery systems with high encapsulation efficiency and low parasite
burden against
Leishmania major
infection. To induce a Th1 type of immune
response and protection against
Leishmania major
infection, DOTAP liposomes
act as a suitable adjuvant and delivery system as compared to free liposome or
free SLA [
34
].
9.1.5 Liposomal Nanomedicine and Stem Cell
Liposomes composed of soya, rapeseed, and salmon lecithin have been reported to
improve cell proliferation on rat bone marrow stem cells (rBMSC) [
76
]. Genetically
modified stem cell therapy with reduced tumorigenic risks and safer applicability
finds wide-scale application in regenerative medicine in the correction of several
diseases. Nanoliposomal delivery of genes for therapeutic and corrective purposes
