Environmental Engineering Reference
In-Depth Information
aggregation with unaltered membrane fluidity. The CLP reveal rapid uptake by rat
aortic endothelial cells with reduced circulation times and poor distribution in
tumors whereas NLP-PEG exhibited the highest anticancer efficacy [
14
].
The surfactant charge (anionic, neutral, and cationic), surfactant carbon chain
length (C4, C12, and C16), and surfactant content (10 %, 20 %, and 29 %) greatly
influences the morphology, physicochemical properties, stability, and permeability
of liposome [
15
].
Liposomes derivatized with lipid-terminated polymer (TAT peptide-liposomes)
were capable of anchoring in the liposomal membrane and increases the uptake of
DNA by liposomes and transfection efficiency in dendritic cell cultures [
16
].
Gold (Au) nanoshells were synthesized using nanoliposome templates and then
grown on the outer surface of the silica shells. DOX drug incorporated liposome/
silicon-di-oxide (SiO
2
)/Au killed cancer cells has higher therapeutic efficacy when
irradiated with near-infrared light. This type of liposome has synergistic effect in
delivering both DOX chemotherapy and photothermal therapy as compared to other
Au nanoshells that cannot carry enough drugs [
17
].
Medium-chain fatty acids (MCFAs) nanoliposomes prepared by high-pressure
micro-fluidization had a strong easy energy supply property, small average diam-
eter, narrow size distribution, great entrapment efficiency with drug loading, and
good stability as compared with crude MCFA liposomes. MCFAs-nanoliposomes
can thus be used as a potential drug candidate for an easy energy supply [
18
].
Soya, rapeseed, and salmon lecithin liposome were stable than other drugs or
liposomes made of pure phospholipids, with respect to their effect on cell prolifer-
ation and metabolic activity on bone marrow stem cells. Lecithin liposome holds
great promise in the future as drug delivery systems for tissue engineering [
19
].
Different techniques like microarray-based immunoassays, enzyme-linked
immunosorbent assay (ELISA), and antibody array are evolving for optimization
of nanoformulations in which the signal-enhancing efficacy is highly increased by
horseradish peroxidase (HRP)-loaded liposomes [
20
].
The response surface methodology (design) was used as an optimal preparation
condition for preparing polyunsaturated fatty acids (docosahexaenoic acid and
eicosapentaenoic acid) nanoliposomes having efficient entrapment efficiency in
pharmaceuticals [
21
].
Emulsion liposomes (eLiposomes) composed of a perfluoropentane nanodroplet
and an aqueous DPPC (di-palmitoyl phosphatidyl choline) liposome interior was
used for carrying anti-cancer drug DOX. The drug delivery release of Dox is
ultrasound sensitive and provides more effective ultrasound therapy for effective
carrier of a chemotherapeutic agent in tumor treatment as it has the potential to
reduce the side effects of cardiotoxicity caused by DOX [
22
].
The lactoferrin nanoliposomes prepared by reverse-phase evaporation method
has better encapsulation efficiency, size distribution, more cellular uptake, higher
stability, and portrays promises for oral administration of lactoferrin, as lectoferrin
is well known for its antioxidant and anticarcinogenic properties [
23
].
