Environmental Engineering Reference
In-Depth Information
Chapter 9
Multidynamic Liposomes in Nanomedicine:
Technology, Biology, Applications,
and Disease Targeting
Shyamasree Ghosh and Waliza Ansar
Abstract Biocompatible and biodegradable liposome nanomedicine are finding
large-scale application in delivery of drugs, RNA, antisense oligonucleotides,
DNA, plasmids carrying gene, antioxidants to targeted sites for diagnosis, and
treatment at cellular and molecular level of disease both in human and life stock.
Conventional drug delivery system suffers from the disadvantage of narrow
therapeutic index, poor serum solubility, and nonspecific target effects.
Circumventing this problem, liposome drug nanoparticles are designed with the
advantage of enhanced permeability, retention effect, selective targeted delivery,
stimuli-induced release that can evade the host defense system, cross the blood-
brain barrier, thus conferring, synergetic effects, small interfering RNA (siRNA)
co-delivery, multimodality therapies, and oral delivery of therapeutics at disease
sites. Liposomes with diverse range of modifications are being designed to generate
improvised medicine delivery systems. Immuno-liposomes, linked with antibodies
are promising tools for targeted drug delivery to specific cancer cells. In the recent
times several anti-cancer agents in nanodelivery systems are under preclinical and
clinical studies. Lipid-based liposomal delivery systems of self-amplifying RNA
vaccines are showing promising effects.
Globally research is being carried out in generating liposomes with higher
compatibility within the biological system in targeting a wide array of diseases
including cancer, overcoming multidrug resistance, inflammatory diseases, throm-
bosis, psoriasis, muscular dystrophy, spinal cord injury, neurologic diseases, dia-
betes, parasite induced diseases, and cardiovascular diseases.
Authors have equal contributions
