Environmental Engineering Reference
In-Depth Information
nanoparticles had a lower viability when compared to similar cells treated
with co-precipitated nanoparticles. Therefore, in terms of cell viability, the
combustion synthesized Fe
3
O
4
proved to be superior to the co-precipitated
magnetite nanoparticles. A very unusual and rare phenomenon was observed
in the case of SK-BR-3 tumor cells treated with combustion synthesized
nanoparticles, as the SK-BR-3 tumor cells were enucleated and lost their
adhesion abilities. On the other hand, in the presence of combustion synthe-
sized nanoparticles normal MSCs developed anchorage structures, which
made them more resistant to the chemical stress.
This remarkable behavior of combustion synthesized magnetite
nanoparticles opens a whole new perspective on the potential use of combus-
tion synthesized Fe
3
O
4
nanoparticles in cancer therapy due to their selective
intrinsic behavior, not only due to their superparamagnetic properties (hyper-
thermia)—as currently reported.
Acknowledgements We would like to thank Alina T
˘
culescu, PhD; Robert Iano
ș
, PhD; and Prof.
Cornelia P
˘
curariu, PhD, Politehnica University Timisoara, for their remarkable contribution in
characterization and synthesis of MNPs.
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