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Fig. 8.
IMGT pMHC contact sites of the human HLA-DRA*0101 and HLA-DRB1*0401
MHC-II and the peptide side chains (9-amino acids located in the groove). (A) 3D structure of
the human HLA-DRA*0101 and HLA-DRB1*0401 groove (1j8h). (B) IMGT pMHC contact
sites IMGT Colliers de Perles. Both views are from above the cleft with G-ALPHA on top and
G-BETA on bottom. In the box, C1 to C11 refer to contact sites. 1 to 9 refer to the numbering
of the peptide amino acids 1 to 9 located in the groove. There is no C5 and C7 in MHC-I 3D
structures with 9-amino acid peptides. There is no C5 in this 3D structure as 5 does not con-
tact MHC amino acids (5N is shown between parentheses in the box). (A color version of this
figure appears between pages 76 and 77.)
