Information Technology Reference
In-Depth Information
T cell receptor
Peptide
MHC
3D
Name Sp.
V-DOMAIN
genes
CDR-
IMGT
Sequence
L
Gene and
allele
1fo0 BM3.3 Mm TRAV16-TRAJ32
[7.7.14] INFDFNTI
8
H2-K1*01
TRBV1-TRBD1-
TRBJ1-3
[6.6.12]
1nam BM3.3
RGYVYQGL
8
1kj2 KB5-
C20
Mm TRAV14-1-TRAJ15 [6.6.11]
KVITFIDL
8
H2-K1*01
TRBV1-TRBD2-
TRBJ2-3
[6.6.16]
(B) TR/pMHC-II
T cell receptor
Peptide
MHC
3D
Name
Sp.
V-DOMAIN
genes
CDR-
IMGT
Sequence
L
Gene and
allele
1fyt
HA1.7
Hs
TRAV8-4-TRAJ48
[6.7.13]
13
HLA-DR
A *0101
PKYVKQNT
LKLAT
Hs
TRBV28-TRBD1-
TRBJ1-2
[5.6.12]
HLA-DR
B1*0101
1j8h
HA1.7
PKYVKQNTL
KLAT
13
HLA-DR
A*0101
HLA-DR
B1*0401
1d9k D10
Mm TRAV14D-2-TRAJ4 [6.6.10]
GNSHRGAIE
WEGIESG
16
H2-AA
*02
TRBV13-2-TRBD2-
TRBJ2-1
[5.6.11]
H2-AB
*02
Each complete TR chain comprises an extracellular region made up of a vari-
able domain and a constant domain (V-ALPHA and C-ALPHA for the
α
chain,
V-BETA and C-BETA for the
β
chain) (Fig. 1), a connecting region, a trans-
membrane region, and a very short intracytoplasmic region. The MHC-I is
formed by the association of a heavy chain (I-ALPHA) and a light chain (
β
-2-
microglobulin B2M, Fig. 1). The MHC-II is a heterodimer formed by the asso-
ciation of an
α
chain (II-ALPHA) and a
β
chain (II-BETA). The I-ALPHA chain
of the MHC-I, and the II-ALPHA and II-BETA chains of the MHC-II comprise
an extracellular region made of three domains for the MHC-I and of two domains
for the MHC-II, a connecting region, a transmembrane region, and an intracyto-
plasmic region. The I-ALPHA chain comprises two groove domains (G-
DOMAIN), G-ALPHA1 [D1] and G-ALPHA2 [D2], and a C-LIKE domain [D3].
The B2M corresponds to a single C-LIKE domain. The II-ALPHA chain and the
II-BETA chain each comprise two domains, G-ALPHA [D1] and C-LIKE [D2],
