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Wiley 2000), 1j8h (Hennecke and Wiley 2002), 1d9k (Reinherz, Tan, Tang, Kern, Liu,
Xiong, Hussey, Smolyar, Hare, Zhang, Joachimiak, Chang, Wagner, and Wang 1999).
Table 1.
TR/peptide/MHC complexes in IMGT/3Dstructure-DB (Kaas et al. 2004),
http://imgt.cines.fr. Sp, species; Hs,
Homo sapiens
; Mm,
Mus musculus
; L, length in amino
acids. Fourteen 3D structures (12 TR/pMHC-I and 2 TR/pMHC-II) correspond to TR
receptors (TR-ALPHA_BETA). Four 3D structures (1d9k, 1fo0, 1kj2, and 1nam) correspond
to an Fv variable fragment (FV-ALPHA_BETA). Gene and allele names are according to
IMGT/GENE-DB (Giudicelli et al. 2005) for human and mouse TR, to IMGT/HLA-DB
(Robinson et al. 2003) for human MHC, and to IMGT for mouse MHC. Amino acid
sequences of the TR V-DOMAINs and MHC G-DOMAINs are reported in Figs. 3 and 4,
respectively. H2-K1*01 encodes H2-K1b, H2-AB*02 and H2-AA*02 encode I-Abk and I-Aak,
respectively. Lengths of the CDR-IMGT are according to Lefranc et al. (2003b).
(A) TR/pMHC-I
T cell receptor
Peptide
MHC
3D
Name Sp.
V-DOMAIN
genes
CDR-
IMGT
Sequence
L
Gene and
allele
1ao7 A6
Hs
TRAV12-2-TRAJ24 [6.6.11]
LLFGYPVYV 9
HLA-
A*0201
TRBV6-5-TRBD2-
TRBJ2-7
[5.6.14]
1qrn A6
LLFGY
A
VYV 9
1qse A6
LLFGYP
R
YV
9
1qsf A6
LLFGYPV
A
V 9
1bd2 B7
Hs
TRAV29/DV5-
TRAJ54
[6.6.10]
LLFGYPVYV
9
HLA-
A*0201
TRBV6-5-
(TRBD2)-TRBJ2-7
[5.6.13]
1oga JM22 Hs
TRAV27-TRAJ42
[5.6.10]
GILGFVFTL
9
HLA-
A*0201
TRBV19-(TRBD2)-
TRBJ2-7
[5.6.11]
1mi5 LC13 Hs
TRAV26-2-TRAJ52 [7.4.14]
FLRGRAYGL 9
HLA-
B*0801
TRBV7-8-
(TRBD2)-TRBJ2-7
[5.6.11]
1lp9 12.2 Mm TRAV12D-2-
TRAJ50
[6.6.13]
ALWGFFPVL
9
HLA-
A*0201
TRBV13-3-
(TRBD2)-TRBJ2-7
[5.6.11]
1g6r 2C
Mm TRAV9-4-TRAJ35 [6.7.10] SIYRYYGL
8
H2-K1*01
TRBV13-2-
(TRBD2)-TRBJ2-4
[5.6.9]
1jtr
2C
EQYKFYSV
8
2dkb 2C
EQYKFYSV
8
1mwa 2C
EQYKFYSV
8
