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Acknowledgements
The author thanks Drs. Y. Sakuraba, H. Sezutsu, K. R. Takahasi, M. Uchiyama,
R. Fukumura, and T. Murata for their contribution in the development of the ENU-
based gene-driven mutagenesis at RIKEN, Y. Nakai, A. Ikeda, N. Fujimoto,
K. Tsuchihashi, Y. Karashima, R. Ichikawa, S. Kaneko, H. Sasaki, K. Takenouchi,
N. Goda, R. Motoi, and K. Karouji for their excellent technical assistance and extensive
data analysis, and in particular the former director, Dr. Akiyoshi Wada, for his lead-
ership, encouragement, and support. This study was partly supported by Grants-in-
Aid for Scientific Research (A) from the Ministry of Education, Culture, Sports,
Science and Technology in Japan.
References
Auerbach, C., and Robson, J.M. (1946) Chemical production of mutations. Nature 157:302.
Augustin, M., Sedlmeier, R., Peters, T., Huffstadt, U., Kochmann, E., Simon, D., Schöniger, M.,
Garke-Mayerthaler, S., Laufs, J., Mayhaus, M., Franke, S., Klose, M., Graupner, A.,
Kurzmann, M., Zinser, C., Wolf, A., Voelkel, M., Kellner, M., Kilian, M., Seelig, S.,
Koppius, A., Teubner, A., Korthaus, D., Nehls, M., and Wattler, S. (2005) Efficient and
fast targeted production of murine models based on ENU mutagenesis. Mamm. Genome
16: 405-413.
Brown, S.D.M., and Nolan, P.M. (1998) Mouse mutagenesis-systematic studies of mammalian
gene function. Hum. Mol. Genet. 7:1627-1633.
Capecchi, M.R. (1989) Altering the genome by homologous recombination. Science
244:1288-1292.
Donehower, L.A., Harvey, M., Slagle, B.L., McArthur, M.J., Montgomery, C.A., Jr., Butel, J.S.,
and Bradley, A. (1992) Mice deficient for p53 are developmentally normal but susceptible
to spontaneous tumours. Nature 356:215-221.
Gao, Q., and Yeung, E.S. (2000) High-throughput detection of unknown mutations by using
multiplexed capillary electrophoresis with poly(vinylpyrrolidone) solution. Anal. Chem.
72:2499-2506.
Gondo, Y., Nakamura, K., Nakao, K., Sasaoka, T., Ito, K., Kimura, M., and Katsuki, M.
(1994) Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem
cells and mice by using two steps of homologous recombination. Biochem. Biophys. Res.
Commun. 202:830-837.
Gondo, Y. (2001) Bioinformatics for the large-scale mouse mutagenesis project. In: N. Baba,
L.C. Jain, and R.J. Howlett (Eds.), Knowledge-Based Intelligent Information Engineering
Systems & Allied Technologies KES'2001 . IOS Press, Tokyo, pp. 763-767.
Hitotsumachi, S., Carpenter, D.A., and Russell, W.L. (1985) Dose-repetition increases the
mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia. Proc. Natl.
Acad. Sci. USA 82:6619-6621.
Hrabé de Angelis, M., and Balling, R. (1998) Large scale ENU screens in the mouse: Genetics
meets genomics. Mutat. Res. 400:25-32.
Little, C.C., and Bagg, H.J. (1923) The occurrence of two heritable types of abnormality
among the descendants of X-rayed mice. Am. J. Roentgenol. Radiat. Ther. 10:975-989.
Liu, G., Parant, J.M., Lang, G., Chau, P., Chavez-Reyes, A., El-Naggar, A.K., Multani, A.,
Chang, S., and Lozano, G. (2004) Chromosome stability, in the absence of apoptosis, is
critical for suppression of tumorigenesis in Trp53 mutant mice. Nat. Genet. 36:63-68.
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