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Fig. 7.
Viral population mean fitness plotted over viral generations for simulations with differ-
ent coreceptor selection coefficient scaling factors. Lines are means of 20 replicate simula-
tions. The antibody production stimulation threshold is 0.1. Other parameter values are as
described in Fig. 5.
component of fitness, but, as expected, resulted in a final functional component of
fitness that is higher than before, around 0.8 (compared to 0.6). Similarly, a scaling
factor of 0.5 also did not alter appreciably the dynamics of the neutralization compo-
nent, but, as expected, resulted in a final functional component of fitness that is
lower than before, around 0.3. Therefore, regardless of the strength of coreceptor
selection, there was a functional cost of adaptation to antibody surveillance, but the
magnitude of the cost depended on the strength of coreceptor selection. Weaker
selection by a coreceptor resulted in a lower cost of adaptation to antibody surveil-
lance.
