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that some cells exhibit premature collapse due to morphological effect and com-
plex load distribution, and both bending and buckling occur in the walls of the
'weak' cells having various shapes and sizes. The finite element simulation based
on the real cell structure extracted from CT images predicts the stress-strain curve
and cell deformation in a reasonable agreement. The numerical prediction can be
improved by developing a more reliable material model for the cell walls and
reducing numerical errors associated with the meshing. The simulation indicates
that significant local yielding occurs well before the plateau regime is reached.
Acknowledgments The authors would like to acknowledge the assistance given by the IT
Services and the use of the Computational Shared Facility at The University of Manchester. The
supports from the Engineering and Physical Science Research Council (EPSRC) grants EP/
F007906/1 and EP/F028431/1 and Royal Society grant JP100958 are also acknowledged. The
first author is grateful for the PhD scholarship from the School of Mechanical, Aerospace and
Civil Engineering, The University of Manchester.
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