Biomedical Engineering Reference
In-Depth Information
Table 3.1
Continued
Class
Assay
Confi guration/principle
Applied force
Advantages
Disadvantages
Parallel plate
+
Direct observation
−
Single force per
Q
wh
6
μ
of attachment/
detachment process
Flow conditions can
experiment
Low applied
τ
=
Q
W
2
−
w
+
forces/limited
to short term
adhesion
Q
= fl ow rate
w
= channel width
h
= channel height
μ
= fl uid viscosity
(
τ
w max
< 120 dyne/cm
2
)
be readily validated
h
Spinning disk
+
Linear gradient of
−
Validation of fl ow
ω
= rotational speed
r
= radial position
ρ
= fl uid density
μ
= fl uid viscosity
(
τ
w max
< 2500 dyne/
cm
2
)
3
08
applied forces
Wide range of
patterns required
End point assay
τ
w
8
r
ρμω
=
ω
+
−
r
applied forces
Uniform chemical
+
conditions at surface
Radial fl ow
+
Gradient of applied
−
Validation of fl ow
3
Q
r h
μ
forces inversely
proportional to radial
position
Direct observation
patterns required
Complex
τ
=
Q
w
2
−
π
Q
= fl ow rate
r
= radial position
h
= gap height
μ
= fl uid viscosity
(
τ
w max
< 600 dyne/cm
2
)
hydrodynamic
conditions at
central fl ow
impingement
point
+
r
of the attachment/
detachment process
Source
: Adapted with permission from Garcia and Gallant, 2003.
