Biomedical Engineering Reference
In-Depth Information
environments, providing a powerful tool for evaluating cell infi ltration
and tissue formation. The application of computational fl uid mechanics
in combination with other imaging and sensing techniques enables better
understanding of the cell environment interactions in 3D, and biological,
physical and chemical principles in engineering various tissues in bioreac-
tors. Advances in fundamental biology and engineering tools will be crit-
ical for reducing bioreactor design failure and will lead to the successful
development of clinically relevant tissues and organs in bioreactors in the
future.
5.9 Sources of further information and advice
The authors understand that the application of bioreactors reaches far
beyond what is described in this chapter. However, the above-mentioned
tissues are most appropriate for a discussion of cell infi ltration. Other tis-
sues that have been grown in bioreactors have been nerves, ligaments,
tendons, osteochondral region, vascular tissues and muscle, among others.
Bioreactors for Tissue Engineering: Principles, Design and Operation
by
Julian Chaudhuri
et al.
offers descriptions and modifi cations to existing
bioreactors. The topic touches on major tissues including those discussed
above.
Bioreactor Systems for Tissue Engineering
by Cornelia Kasper
et al.
also offers more recent insights into bioreactor advancement. This topic
provides more in-depth background to studies conducted for various tis-
sues.
Cell and tissue reaction engineering
by Regine Eibl
et al.
offers an
excellent chapter outlining different types of bioreactors used for mam-
malian cell cultures. In addition, Ivan Martin offers some great perspec-
tives on commercial aspects of bioreactors and the potential of using
computational fl uid mechanics and µCT technologies to optimise limi-
tations that arise in bioreator studies.
Bone and cartilage engineering
by
Ulrich Meyer
et al.
provides some insight into the mechanical stimulation
that bioreactors have to offer in bone and cartilage engineering. Catapano
and Gerlach (2007) offer a very descriptive topic chapter on Liver Tissue
Engineering.
5.10 References
Allen , J.W. and Bathia , S.N. ( 2002 ), ' Engineering live therapies for the future ',
Tissue
Eng
,
8
(5), 725 -37.
Altman , G.H. , Horan , R.L. , Martin , I. , Farhadi , J. , Stark , P.R.H. , Volloch , V. , Richmond ,
J.C. , Vunjak-Novakovic , G. and Kaplan , D.L. ( 2002 ), ' Cell differentiation by
mechanical stress',
FASEB J
,
16
, 270 -2.
Appelman , T.P. , Mizrahi , J. , Elisseeff , J.H. and Seliktar , D ( 2009 ), ' The differential
effect of scaffold composition and architecture on chondrocyte response to
mechanical stimulation',
Biomaterials
,
30
(4), 518 -25.
