Chemistry Reference
In-Depth Information
cross-coupling selectivity of 93% and estimated enantioselectivity of 43% ee (
S
) [122] .
Kozlowski and coworkers have demonstrated that the one-pot tandem AOCP/Glaser
coupling of
77
in the presence of copper catalyst (
78
) was effective to synthesize highly
functionalized polybinaphthyls (
79
) (Scheme 13.11 ) [123,124] .
HO
CO
2
R
PivO
CO
2
Hex
PivO
OH
OH
HexO
2
C
OH
73a
: R = Me
73b
: R = Bn
74
75
HO
CO
2
Bn BnO
2
C
OH
HO
BnO
2
C
OH
HO
OH
HH
O
BnO
2
C
HH
O
BnO
2
C
HH
O
CO
2
Bn
n
X
Y
Z
76
HO
H
RO
2
C
N
CO
2
R
Cu
+
BF
4
−
N
H
CO
2
R
78
OH
OH
∗
OH
O
2
OH
77
CO
2
R
(R =
n
-C
6
H
13
)
n
RO
2
C
HO
79
Scheme 13.11.
