Chemistry Reference
In-Depth Information
Br
Mes
N
OH
OH
+
N
OMe
Br
Mes
O
H
+
12
(50% ee, 10 mol %)
13
(10 mol %)
Et
2
Zn (14 mol %)
O
+
H
Ph
Ph
O
OTMS
Toluene, -20
°
C
ca. 90% ee
O
Zn
R
N
O
O
O
Zn
R
R
Zn
N
O
O
Active catalyst
Homochiral dimer
N
O
O
Zn
R
Zn
R
N
O
O
O
S
N
Zn
O
O
Zn
S
Heterochiral dimer
N
O
Scheme 12.19.
Sc(OTf)
3
(10 mol %)
14
(20% ee, 20 mol %)
p
-NH
2
C
6
H
4
SO
3
H
THF, rt
HO
OH
OMe
1 N HCl
N
+
N
OTMS
Ph
H
Ph
O
ca. 50% ee
i
-Pr
i
-Pr
i
-Pr
NH
HN
i
-Pr
O
O
O
O
N
N
14
Scheme 12.20.
