Chemistry Reference
In-Depth Information
O
O
O
O
P
HN
P
O
O
Ph
O
O
P
P
O
O
O
Ph
O
H
3
C
N
P
O
O
O
O
=
a
,
b
O
H
3
C
N
P
Ph
O
51
52
53
(ee's up to 8%)
(ee's up to 65%)
(ee's up to 58%)
O
O
O
X
O
O
O
P
P
P
N
HN
RS
O
O
O
O
P
OO
P
OO
O
O
O
O
=
c
,
j
,
k
=
j
,
k
O
O
O
=
a
O
54
55
X= CH
2
X= CO
56
R= Me,
i
Pr, Ph
57
(ee's up to 19%)
(ee's up to 32%)
(ee's up to 5%)
N
N
O
O
O
O
O
O
=
j
,
K
O
O
=
a
,
j
P
O
P
O
59
58
(ee's up to 5%)
(ee's up to 5%)
Figure 10.11.
Miscellaneous of heterodonor ligands
51
-
59
. Enantioselectivities are shown in
brackets.
H
2
/CO
CHO
+
AcO
AcO
CHO
AcO
*
[M-Chiral Catalysts]
Scheme 10.4.
10.2.4. Rhodium - Catalyzed Asymmetric Hydroformylation of Vinyl acetate
The Rh-catalyzed asymmetric hydroformylation of vinyl acetate is generally more chal-
lenging than the hydroformylation of vinylarenes. This process yields 2- and 3- acetoxy-
propanals with high selectivity (Scheme 10.4 ).
