Chemistry Reference
In-Depth Information
TABLE 8E.5. Catalytic Enantioselective ROCM Reactions of meso - Azabicycles
OTBS
OTBS
Mo- or Ru-based
chiral catalyst
Me
N
Me
Ph
Ph
Chiral catalysts:
N
Me
Mo
O
Ph
Me
O
2
MesN
N
Cl
Ru
O
Oi-Pr
Ph
11a
Conv (%);
Yield (%)
Entry
Product
Catalyst; mol %
Time (h)
ee (%)
1
2
; 5
1
> 98; 95
94
OTBS
2
11a
; 5
36
30; nd
33
Me
Ph
3
2
; 5
1
> 98; 85
21
OTBS
4
11a
; 5
24
> 98; 80
> 98
Bn
Ph
5
2
; 10
24
83; 80
82
6
11a
; 10
24
91; 70
− 90
Cbz
Ph
nd = not determined. All reactions performed at 22 ° C.
