Chemistry Reference
In-Depth Information
Ar = 2,4,6-i-Pr
3
C
6
H
2
5 mol %
Cl
Cl
N
Ar
Me
O
Mo
O
Ph
O
Me
Ph
Ar
O
O
Ph
3b
H
C
6
H
6
, 22
°
C,12 h
93% yield, 86% ee
5 mol %
N
Me
Mo
O
Ph
Me
O
O
H
O
2
H
C
6
H
6
, 22
°
C, 3 h
80% yield, 96% ee
5 mol %
i-Pr
i-Pr
N
Me
Mo
O
Ph
Me
O
O
Me
Polymerization
1a
C
6
H
6
, 22
°
C
Ar = 2,4,6-i-Pr
3
C
6
H
2
3 mol %
i
-Pr
i
-Pr
N
Ar
Me
O
Mo
O
Ph
Me
Me
OTBS
Me
Me
O
OH
Me
Me
TBSO
Ar
Me
Me
H
H
3a
Me
(+)-Africanol
97% yield, 87% ee
No solvent, 22
°
C, 6 h
Scheme 8E.10.
Mo-catalyzed enantioselective RORCM of norbornenes: application to enantiose-
lective synthesis of africanol.
