Chemistry Reference
In-Depth Information
ent-
39a
(10 mol %)
OCH
2
CF
3
+
OCH
2
CF
3
23°C, neat
O
O
>97% ee (97%)
3 steps
O
AcHN
I
+
OEt
H
3
N
H
2
PO
4
-
8 steps
HN
.
O
O
Tamiflu
Scheme 8D.65.
H
Ph
Ph
B
O
N
H
F
NTf
2
H
40
(20 mol %)
H
H
m
m
O
O
Toluene, r.t., 20 h
n
H
n
O
O
m
= 2,
n
= 1
m
= 1,
n
= 1
m
= 1,
n
= 2
90% ee, dr >19:1 (69%)
92% ee, dr >19:1 (80%)
90% ee, dr 5.9:1 (78%)
Scheme 8D.66.
H
Ph
Ph
N
B
O
Br
3
Al
Me
O
R
O
R
H
41
(4 mol %)
OEt
CO
2
Et
+
O
EtO
CH
2
Cl
2
, -40
°
C
CO
2
Et
R
H
R
O
R = H (16 h)
R = Me (24 h)
99% ee (71%)
91% ee (72%)
(8 mol %)
Scheme 8D.67.