Chemistry Reference
In-Depth Information
HO
23c
CH
3
CH
3
CHO
(10 mol %)
OHC
CHO
OH
MS 4A
H
3
C
R
HO
H
R
H
Toluene, r.t.
R
% yield
dr
% ee
R =
46
>30:1
92
42
>30:1
93
R =
Scheme 8D.42.
R
[Rh(diphosphine)Cl]
2
(3-5 mol %)
AgSbF
6
(3-5 mol %)
(CH
2
Cl)
2
, r.t.
R
X
O
96% ee (62%)
98% ee (67%)
82% ee (98%)
X = O, R = Ph
X = O, R = C
4
H
9
X =PhSO
2
N, R = Me
P
PPh
2
PPh
2
OPPh
2
H
H
H
H
P
OPPh
2
(
R
,
R
,
R
,
R
)-BICPO
(
R
,
R
)-Me-Duphos
(
R
,
R
,
R
,
R
)-BICP
Scheme 8D.43.
[Rh(cod)Cl]
2
(5 mol %)
R
1
R
2
(
S
)-BINAP (12 mol %)
R
1
R
2
AgSbF
6
(20 mol %)
(CH
2
Cl)
2
, r.t.
*
O
O
R
1
= Ph, R
2
= H
R
1
= Me, R
2
= Me
R
1
= CO
2
Et, R
2
= Et
R
1
= CH
2
OH, R
2
= Me
R
1
= Me, R
2
= OAc
>99.5% ee (96%)
>99.9% ee (82%)
>99.9% ee (82%)
>99% ee (81%)
>99.9% ee (92%)
Scheme 8D.44.
