Chemistry Reference
In-Depth Information
Ar
Br
N
R
1
O
2
N
R
1
NO
2
108
(1 m
ol %)
Ar
CO
2
R
3
CO
2
R
3
108
CH
2
O
2
R
3
R
2
+
Toluene, base
R
2
F
3
C
CF
3
CO
2
R
3
Up to 99% yield
syn
/
anti
: up to 5/95
Up to 99% ee (anti)
R
1
=Et,Me,Me
2
CH
R
2
= c-hex, 2-naphyl, Ph
R
3
=E ,
i
Pr,
i
Bu
Ar =
CF
3
CF
3
Ar
Br
N
R
NO
2
O
+
109
(1 mol %)
OH
Ar
109
Toluene, base
R
F
n
F
F
n
=1,2,3
N
O
2
n
n
=1,2,3
Up to 99% yield
syn
/
anti
: up to 95/5
Up to 93% ee
R=Bn,Et,
i
Pr
Ar =
F
F
F
Scheme 8A.57.
R
2
Catalyst
110
(20 mol %)
DNBA (20 mol %)
CH
2
Cl
2
/H
2
O
R
1
O
O
O
CH
3
O
+
R
3
N
O
R
1
TMSO
O
R
2
R
3
H
R
1
= H, Me, Et, CO
2
Et
R
2
= H, Me
R
3
= Me, Pr, Pr
i
, Ph, CH
2
OBz
Up to 87%
syn
/
anti
: up to 96/4
Up to 99%ee
110
Scheme 8A.58.
