Chemistry Reference
In-Depth Information
Reaction
Conditions
% ee
(Confi g.)
Catalyst
R
X
n
S
/
C
Reference
[Ru - (
S
) - BINAP]Br
2
Ph
NMe
2
1
490
MeOH,
20 - 32 ° C,
100 atm
H
2
95 (
S
)
18b
RuI[(
S
) - BINAP)]
(
p
- cymene)I
Me
NMe
2
1
1,100
CH
2
Cl
2
/
MeOH,
30 ° C,
105 atm
H
2
99.4 (
S
)
235
trans
- RuCl
2
[(
R
) -
XylBINAP]
[(
R
) - daipen]
Me
NMe
2
1
2,000
t
BuOK,
i
92 (
S
)
265
PrOH,
25 ° C,
8 atm H
2
trans
- RuCl
2
[(
R
) -
XylBINAP]
[(
R
) - daipen]
Ph
NMe
2
1
2,000
t
BuOK,
i
93 (
R
)
265
PrOH,
25 ° C,
8 atm H
2
trans
- RuCl
2
[(
R
) -
XylBINAP]
[(
R
) - daipen]
Ph
N(Ac)Me
1
2,000
t
BuOK,
i
PrOH,
25 ° C,
8 atm H
2
99 (
R
)
265
trans
- RuCl
2
[(
R
) -
XylBINAP]
[(
R
) - daipen]
Ph
N(Boc)Me
1
2,000
t
BuOK,
i
PrOH,
25 ° C,
8 atm H
2
99 (
R
)
265
trans
- RuCl
2
[(
R
) -
XylBINAP]
[(
R
) - daipen]
Ph
NMe
2
2
10,000
t
BuOK,
i
PrOH,
25 ° C,
8 atm H
2
97.5 (
R
)
265
[NH
2
Me
2
]
[{RuCl[(
S
) -
TunePhos]}
2
( μ - Cl)
3
]
Ph
Phthalimide
1
100
EtOH,
80 ° C,
1500 psi
H
2
98.5
23d
[NH
2
Me
2
]
[{RuCl[(
S
) -
TunePhos]}
2
( μ - Cl)
3
]
Me
Phthalimide
1
10,000
EtOH,
80 ° C,
100 bar
H
2
> 99 (
S
)
23d
[NH
2
Me
2
]
[{RuCl[(
R
) -
8
]}
2
(
Ph
Phthalimide
1
100
EtOH,
80 ° C,
1500 psi
H
2
99
269
μ
-
Cl)
3
]
(
R,R
) - Me - DuPhos - Pd
Ph
Phthalimide
1
50
TFE, 50 ° C,
200 psi H
2
91.7 (
R
)
270
395
