Chemistry Reference
In-Depth Information
TABLE 7.11.
(
Continued
)
Reaction
Conditions
% ee
(Confi g.)
Catalyst
R
1
X R
2
S
/
C
Reference
Ru(
89
)Br
2
Me
OEt
200
EtOH, 50 ° C,
50 atm H
2
95.5 (
R
)
8 2
Ru[(
R,R
) -
i
Pr - BPE]Br
2
Me
OMe
500
MeOH/H
2
O,
35 ° C, 60 psi H
2
99.3 (
S
)
28a
Ru[(
S,S
) -
t
Bu - BisP * ] Br
2
Me
OMe
200
MeOH/H
2
O,
70 ° C, 6 atm H
2
98
240
(
R
) - (
S
) - Josiphos - Rh
Me
OEt
100
MeOH, rt, 20 atm
H
2
97 (
S
)
8 0
RuCl
2
[(
R
) - C
3
* -
TunePhos](DMF)n
Me
OEt
667
MeOH/CH
2
Cl
2
,
70 ° C, 50 psi H
2
,
24 h
> 99 (
R
)
24a
RuCl
2
[(
S,S,R,R
) -
TangPhos](DMF)n
Me
OEt
1,000
MeOH/H
2
O,
50 ° C, 5 atm H
2
99.8 (
R
)
249
RuBr
2
[(
R
) - BINAP]
Ph
OEt
760
MeOH, 23 - 30 ° C,
91 atm H
2
85 (
S
)
18a
RuBr
2
[(
R
) - MeO -
BIPHEP]
Ph
OEt
50
EtOH, 50 ° C,
1 atm H
2
96 (
S
)
239c
Ru[(
) - TetraMe -
BITIOP]Cl
2
−
Ph
OEt
257
MeOH/H
2
O,
45 ° C, 100 atm
H
2
93 (
S
)
196
[NH
2
Me
2
]
[{RuCl[(
R
) -
SEGPHOS]}
2
(
Ph
OMe
10,000
MeOH, 80 ° C,
30 atm H
2
97.6 (
S
)
21b
μ
- Cl)
3
]
Ph
OEt
100
EtOH, 80 ° C,
10 bar H
2
206
Ru[(
R
) - difl uorphos]Br
2
92 (
S
)
Ph
OEt
100
MeOH, rt,
1400 psi H
2
250
Ru[(
R
) -
8
]Cl
2
99.5 (
S
)
{Ru[(
R
) - 4,4
-
diamBINAP]Br
2
}(Br)
2
′
Ph
OMe
1000
H
2
O, 50 ° C, 40 bar
H
2
99 (
S
)
246
Ru(
92
)Br
2
Ph
OEt
200
MeOH, 50 ° C,
50 atm H
2
96 (
S
)
8 2
Ru[(
R
) - Xyl - P - Phos)]
(C
6
H
6
)Cl
2
Ph
OEt
800
EtOH/CH
2
Cl
2
,
90 ° C, 300 psi H
2
96.2 (
S
)
132
Ru[(
S
) - Xylyl -
o
-
BINAPO)]Cl
2
(DMF)
n
Ph
OEt
100
EtOH/CH
2
Cl
2
,
50 ° C, 80 psi H
2
99 (
R
)
136
RuBr
2
[P,P -
ClickFerroPhos]
Ph
OEt
200
EtOH, 50 ° C,
10 atm H
2
98 (
S
)
5 1
