Chemistry Reference
In-Depth Information
O
O
Rh
•L-17
MeO
CO
2
Me
MeO
CO
2
Me
H
2
(30 bar), CO
2
40-45°C
72% ee
+
Ar
Ar
CF
3
OP
-
B
Rh
OP
CF
3
Ar
Ar
4
Ar =
CH
2
CH
2
(CF
2
)
6
F
Rh•
L-17
Scheme 1.30.
P
PPh
2
F
e
Josiphos 001 (
L-18
)
Scheme 1.31.
Scheme 1.32.
perfl uoroalkyl groups are used. scCO
2
is utilized to dissolve H
2
and for ease of product
separation.
A similar fl ow system with an immobilized chiral Ru•
L - 19
complex for asymmetric
cyclopropanation reaction in scCO
2
has been reported. It is demonstrated that produc-
tivity in scCO
2
has been increased 7.7-fold compared with that in DCM. Environmental
friendliness and ease of product separation are further merits (Scheme 1.32) [47].
