Chemistry Reference
In-Depth Information
O
OMe
MeO
O
OMe
O
S
-cat
.
O
O
O
O
O
49
50
67% yield
95% ee
(+)-Isodeoxypodophyllotoxin
O
O
O
O
R
-
cat.
OH
MeO
MeO
51
52
O
62% yield
93% ee
(-)-Enterolactone
Rh
2
(4
S/R
-MPPIM)
4
CH
2
Cl
2
, 40°C
O
N
2
O
R
48
OH
O
MeO
S
-cat.
MeO
HO
TBDPSO
OH
MeO
53
54
68% yield
93% ee
(
S
)-(+)-imperanene
O
CO
2
H
O
H
2
N
HCl
S
-cat.
Cl
Cl
55
56
81% yield
95% ee
(
R
)-(-)-baclofen HCl
Scheme 4.12.
Synthetic applications of stereoselective γ - lactone formation.
