Biomedical Engineering Reference
In-Depth Information
Fig. 4.2
A matrix with 340 odorant-receptor pairs, involving a total of 62 human and mouse ORs
and 63 odorants. Odorants on the
x
-axis are ordered and color-coded by functional groups and
ORs on the
y
-axis by number of agonists. The heat map color scale represents EC
50
values of the
different odorant-receptor interactions. Class I ORs are shown in
green
and class II ORs in
purple
.
Human ORs are shown on a
gray
background. (Modified with permission from [
17
]. Copyright
2009,
Science Signaling
)
et al. and Nara et al. found broadly- and narrowly-tuned ORs, they found that a larger
proportion of mouse OSNs were narrowly tuned with only a very small proportion
being broadly tuned. Of the 97 OSNs that responded to only one odorant mixture,
43 responded to only one odorant. There is one case in which one OSN correspond-
ing to Olfr42 was activated by 12 single odorants. While the apparent differences in
olfactory response profiles between the two studies may indicate that odor tuning of
Search WWH ::
Custom Search