Olfactory Receptor Proteins - Bioelectronic Nose: Integration of Biotechnology and Nanotechnology - page 50

Table 3.1 (continued)

Receptor Class/ a

subclass

Year PDB code Resolution (Å) Ligand Type b Conformational state Reference

Human chemokine
CXCR4

R/γ 2010 3ODU 2.5 IT1t Antagonist Inactive Wu et al. [ 90 ]

2010 2OE0 2.9 CVX15 Antagonist Inactive Wu et al. [ 90 ]

Human dopamine D3 R/α 2010 3PBL 2.9 Eticlopride Antagonist Inactive Chien et al. [ 91 ]

Human histamine H1 R/α 2011 3RZE 3.1 Doxepin Inverse agonist Inactive Shimamura et al. [ 92 ]

Human sphingosine
1-phosphate

R/α 2012 3V2Y 2.8 ML056 Antagonist Inactive Hanson et al. [ 93 ]

Human M2 muscarinic
acetylcholine

R/α 2012 3UON 3.0 QNB Antagonist Inactive Haga et al. [ 94 ]

Rat M3 muscarinic
acetylcholine

R/α 2012 4DAJ 3.4 Tiotropium Inverse agonist Inactive Kruse et al. [ 95 ]

Mouse μ-opioid R/γ 2012 4DKL 2.8 β-FNA Irreversible

antagonist

Inactive Manglik et al. [ 96 ]

Human κ-opioid R/γ 2012 4DJH 2.9 JDTic Selective

antagonist

Inactive Wu et al. [ 77 ]

Mouse δ-opioid R/γ 2012 4EJ4 3.4 Naltrindole Selective

antagonist

Inactive Granier et al. [ 97 ]

Human nociceptin/
orphanin FQ

R/γ 2012 4EA3 3.0 C-24 Antagonist Inactive Thompson et al. [ 98 ]

Rat neurotensin R/β 2012 4GRV 2.8 Neurotensin Agonist Intermediate White et al. [ 99 ]

Human protease acti-
vated receptor 1

R/δ 2012 3VW7 2.2 Vorapaxar Antagonist Inactive Zhang C. et al. [ 100 ]

Human chemokine
CXCR1

R/γ 2012 2LNL NMR - - inactive Park et al. [ 28 ]

a GRAFS classification [ 6 ]
b see Fig. 3.1
Ternary complex with: c 11 amino acid C terminal fragment of Gt α-subunit, d camelid nanobody, e Gs protein