Biomedical Engineering Reference
In-Depth Information
Fig. 2.13 (a) Mixed alginate
chitosan-sugar cylindrical hydrogel containing silver
nanoparticles. (b) Alginate-silver microspheres. (c) Cytotoxicity analysis (MTT assay) on
mouse fibroblast (NIH-3T3), human hepatocarcinoma (HepG2), and human osteosarcoma
(MG63) cell lines of functional gel microspheres external solutions (S1 and S2, external solutions
not diluted and 1:10 diluted, respectively; T, cytotoxicity positive control, cells treated with Triton
1 %; CTRL, cytotoxicity negative control, cells treated with 0.015 M NaCl solution). (d) Growth
of
S. epidermidis
on 20 % Mueller
Hinton AC gel (
upper Petri dish
) and on 20 % Mueller
Hinton AC-nAg gel (
lower Petri dish
) (Travan et al.
2009
)
wider spectrum wound sterilization and healing performance. A recent study
evaluated the biological performance of hydrogels based on alginate, chitosan,
and hyaluronic acid blends, which were found to enhance tissue generation. Fur-
thermore, in order to obtain a hydrogel not only with a tissue generation enhance-
ment ability but also with an antimicrobial ability to avoid infections, Ce(III) ions
were incorporated in one of these hydrogels, and its biological performance was
also studied and effectiveness of Ce(III) was demonstrated (Morais et al.
2013
).
Fluorinated chitosan hydrogels were shown to be highly effective in wound
treatment (Wijekoon et al.
2013
). Recently, series of novel, biocompatible hydro-
gels able to repeatedly take up and deliver oxygen at beneficial levels have been
developed by conjugating various perfluorocarbon (PFC) chains to methacrylamide
chitosan via Schiff base nucleophilic substitution, followed by photopolymerization
to form hydrogels. This new class of fluorinated and biologically derived chitosan
materials can be formed into injectable or moldable photo-cross-linked hydrogels
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