Functional model oxygenations by nonheme iron complexes - Advances in Catalytic Activation of Dioxygen by Metal Complexes - page 168

The functional model oxygenations above mentioned are all for catechol 1,2-
dioxygenases (CTD) or protocatechuate 3,4-dioxygenases (3,4-PCD). However,
there is another group of catechol dioxygenases, chlorocatechol dioxygenases
(CCD). These dioxygenases are characteristic of the low substrate specificity and
catalyze the intradiol cleavage of not only mono or di-halogenated catechols, but
also other various catechols. 4 The function and structure of this type of enzymes are
not well characterized, 58, 59, 65, 66 but development of the functional model
oxygenations is a very attractive object from both sides of basic and applied
sciences, especially environmental sciences. Funabiki et al. was successful to
develop the functional model oxygenation of 3- or 4-chlorocatechol by using TPA as
a ligand (eq. 3). 109