Chemistry Reference
In-Depth Information
SCHEME 2.10
Overall synthetic route for
the 32-amine-terminated G4 polyamide
dendrimer.
and trifluoroacetamide as the protecting group for the end amine, in which the
number of amide units dramatically propagated only through every deprotection
and condensation.
Trifluoroacetamide-protected trimer
19
was synthesized from protected monomer
17
utilizing a one-pot multiple addition condensation reaction. It is
noteworthy that this approach enables four reactions, two times of activation and two
times of condensation, to be carried out in one pot. Thus, the nonamer
23
was obtained
only through five-step processes. In addition, all the products are purified using only
crystallization or precipitation.
The synthesis of dendron-rod molecules were grown by divergent approach from
the secondary amine group of N-butylated nona(p-benzamide)
and monomer
16
23
using 3,5-bis
