Chemistry Reference
In-Depth Information
SCHEME 2.8
Rapid synthesis of polyamide dendrimer from unprotected AB
2
.
groups at the dendrimer periphery and the quantitative condensation of the
resulting active intermediates with AB
2
-building blocks without side reactions
such as the hydrolysis of active intermediates, which would result in the formation
of defects, in a divergent approach.
Authors have developed a two-step method for the facile synthesis of amine-
terminated aromatic polyamide dendrimers using 3,5-bis(trifluoroacetamido)benzoyl
chloride
as an novel AB
2
-building block via a divergent approach in which the
condensation and deprotection reactions are carried out rapidly in one pot [24].
The G1 dendrimer was prepared using p-phenylenediamine (PDA) as a core
molecule in one pot (Scheme 2.9). Further, 1.1 equiv. of AB
2
-building block
15
was
added to each amino group in a solution of PDA in N-methyl-2-pyrrolidinone (NMP)
at 0
C and stirred for 1 h at room temperature to yield the trifluoroacetyl-terminated
15
