DEGRADABLE DENDRIMERS - Designing Dendrimers - page 424

TABLE 13.1 Nonexhaustive List of Applications Related to Cleavable Dendrimers and Cleaving Methods

Approx. Dates
of Important
Activities

Research Activities
(Rated by No. of
Publications)

Applications Cleaving Methods

1996 First gene transfer with degraded dendrimers

and enzymatic cleavage of dendrimers

Hydrolytic, pH dependent

2004 Glycodendrimers-solid-phase synthesis Hydrolytic, photolytic, metal-catalyzed

2002-2006 Degradable-biocompatible materials Photolabile, enzymatic, hydrolytic

2003- Tissue repairs—ocular sealant for sutureless

eye-surgery

Biodegradation, hydrolytic

2002-2009 Anticancer—chemotherapeutics-drug release

polytherapy, drug solubilization, prodrugs,
drug nanocarriers, and so on

Enzymatic, catalytic antibodies, hydrolytic,
metal-mediated, photolabile, chemical
trigger

2003 Fundamental studies (chemical adaptor units—

chemical triggers)

Redox, hydrolytic, photolabile, enzymatic,
metal-catalyzed, and so on

2000 Chemically amplified photoresists Photolytic

1995-1996 First molecular imprints with dendrimers Hydrolytic

2002 Fragrance release Hydrolytic

2006 Gas release Hydrolytic

2001 Pesticide release Hydrolytic

2003-2006 Nonsteroidal antiinflammatory drugs Hydrolytic, enzymatic

1999 Steroids Hydrolytic