Chemistry Reference
In-Depth Information
FIGURE 13.5
Supramolecular assembly of dendrimers and entrapment of the conjugates
followed by a disassembly of the architecture.
FIGURE 13.6
Covalent disassembly of a dendrimer-conjugate.
reactions must occur to break some bonds. It could also be called a chemical
degradation, via some elimination reactions, and the dendrimer fragmentation could
be complete or not. The degradation would usually be stepwise, as shown in
Figure 13.6.
13.2.1.6 Encapsulation of the Conjugates in a Core-Shell Dendrimer and a
Covalent Disassembly of the Shell will Release the Conjugates A core-shell
architecture concept is presented in Figure 13.7. A covalent mode of degradation
will promote the cleavage of some bonds and a disassembly of a dendritic shell. It could
then initiate a supramolecular disassembly of an inclusion complex. The dendritic
shell could be made from dense, tight dendritic peripheral labile functions [88-90]
(such as in a dendritic box [91]) or from a degradable covalent matrix [92].
FIGURE 13.7
Encapsulation of the conjugates in a core-shell dendrimer and a covalent
disassembly of the shell with a release of the conjugates.
