Chemistry Reference
In-Depth Information
SCHEME 13.2
Analysis of the degree of branching by degradation of poly(aryl ester)
dendrimers.
acid and trimesic acid [54]. Seebach and coworkers investigated the mode of cleavage
of several dendrimers using various types of enzymes (Scheme 13.3). More details
will be given elsewhere in this chapter. In the same year, followed an in vitro gene
delivery by some degraded poly(amidoamine) (PAMAM) dendrimers, called
“fractured dendrimers,” obtained after a heat-treatment in a solvent [55]. As described
above, we may suppose that many retro-Michael additions and other side-reactions
took place. Some degraded PAMAM dendrimers were more effective than the native
dendrimers. Starting from the experience on a fully degradable hyperbranched poly
SCHEME 13.3
Enzymatic degradation of (R)-3-hydroxy-butanoic acid derivatives and
dendrimers.
