Chemistry Reference
In-Depth Information
FIGURE 1.8
Mathematical expressions for calculating the theoretical number of surface
groups (Z), branch cells (BC), and molecular weights (Mw) for [core:1, cystamine]; (G
¼
0-7);
{dendri-poly(amidoamine)-(NH
2
)
Z
} (PAMAM) dendrimers as a function of generation. Ap-
proximate hydrodynamic diameters (G
¼
0-7) based on gel electrophoretic comparison for the
corresponding PAMAM dendrimers.
Dendrimer mass and size uniformity has been exhaustively demonstrated by ESI/
MALDI-TOF mass spectrometry [29], gel electrophoresis [30-32,39], electron
microscopy (TEM) [40], (Figure 1.10), atomic force microscopy (AFM) [41] and
other methodologies, to mention a few [42]. Within a specific dendrimer family, it is
possible to produce a systematic, reproducible continuum of nano-sizes and precise
masses as a function of generations (see Figures 1.8-1.10). It should be noted, that
dendrimer mass approximately doubles, generation to generation, with a remarkable
uniformity of mass distribution over five generations exhibiting polydispersities
ranging from 1.005 to 1.130.
FIGURE 1.9
Molecular simulations for [core:NH
3
]; (G
¼
0-5); {dendri-poly(amidoamine)-
(NH
2
)
n
} (PAMAM) dendrimers and a generational comparison of hydrodynamic diameters.
(See the color version of this figure in Color Plates section.)
