Biomedical Engineering Reference
In-Depth Information
that, although showing a positive clinical outcome, the bone tissue engineering
construct of this study only partially exploited the ideal features of a tissue
engineering construct as described in this chapter.
14.8 Conclusions
the impressive progress in knowledge that has been made in the last few
decades in the field of biomaterials and cell biology has created a unique
technological platform for the development of bone tissue engineering
constructs able to aid bone repair in critical clinical scenarios. However,
despite the efforts made by members of the scientific community to highlight
the characteristics of an ideal bone tissue engineering construct, information
contained in the vast literature body is still relatively scattered and only
partially addresses the clinical problems. although most of the research is
conducted using a multi-disciplinary approach, only the major components
required in bone repair are taken into account and other key elements of
this complex pattern are neglected or not fully integrated. it is time for
scientists and policy makers to produce coordinated projects where biological,
pathological and procedural requirements are addressed by the combined
effort of scientists, industrialists and clinicians.
14.9 References
Beppu MM, Torres MA, Aimoli CG, Goulart GAS and Santana CC (2005). '
In vitro
mineralization on chitosan using solutions with excess of calcium and phosphate
ions'.
J Mat Res
,
20
(12), 3303-11.
Bieback K, Kern S, Kocaomer A, Ferlik K and Bugert P (2008). 'Comparing mesenchymal
stromal cells from different human tissues: bone marrow, adipose tissue and umbilical
cord blood'.
Biomed Mater Eng
,
18
(1), S71-6.
Boland t, Ovsianikov a, Chickov Bn, Doraiswamy a, narayan RJ, Yeong WY, Leong
KF and Chua CK (2007). 'Rapid prototyping of artificial tissues and medical devices'.
Adv Mater Processes
,
165
(4), 51-3.
Cancedda R, Dozin B, Giannoni P and Quarto R (2003). 'Tissue engineering and cell
therapy of cartilage and bone'.
Matrix Biol
,
22
, 81-91.
Caplan AI (1991). 'Mesenchymal stem cells'.
J Orthop Res
,
9
, 641-50.
Carinci F, Palmieri a, Martinelli M, Perrotti V, Piattelli a, Brunelli G, arlotti M and
Pezzetti F (2007). 'Genetic portrait of osteoblast-like cells cultured on PerioGlas'.
J
Oral Implantol
,
33
(6), 327-33.
Catelas I, Sese N, Wu BM, Dunn JCY, Helgerson S and Tawil B (2006). 'Human
mesenchymal stem cell proliferation and osteogenic differentiation in fibrin gels
in
vitro
'.
Tissue Eng
,
12
(8), 2385-96.
Chow M, Duong H, Wu B and Tawil B (2008). 'Mesenchymal stem cells differentiation into
osteoblasts on 2D and in 3D fibrin scaffolds'.
Wound Rep Reg
,
16
(2), A10-A58.
Chung HJ and Park TG (2007). 'Surface engineered and drug releasing pre-fabricated
scaffolds for tissue engineering'.
Adv Drug Del Res
,
59
, 249-62.
